SYNERGISTIC INDUCTION OF MITOTIC PYROPTOSIS AND TUMOR REMISSION BY INHIBITING PROTEASOME AND WEE FAMILY KINASES

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Abstract Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells.Whether pyroptosis can be a death form of MC remains unknown.Proteasome-mediated protein degradation is crucial for M-phase.Bortezomib (BTZ), which inhibits the 20S catalytic particle of proteasome, is Je

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Acceptability of emergency contraception in Brazil, Chile, and Mexico: 1 - Perceptions of emergency oral contraceptives

This article presents the results of a study on the acceptability of emergency contraception (EC) in Brazil, Chile, and Mexico.Opinions of potential users Work Benches and possible providers were obtained through discussion groups and those of authorities and policy-makers through semi-structured interviews.Most participants had a positive opinion

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